Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62:1211-1218 (2007)
© 2007 The Gerontological Society of America

Effect of Lifelong Coenzyme Q10 Supplementation on Age-Related Oxidative Stress and Mitochondrial Function in Liver and Skeletal Muscle of Rats Fed on a Polyunsaturated Fatty Acid (PUFA)-Rich Diet

Julio J. Ochoa, José L. Quiles, Magdalena López-Frías, Jesús R. Huertas and José Mataix

Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain.

Address correspondence to Julio J. Ochoa, PhD, Institute of Nutrition and Food Technology. C/Ramón y Cajal, 4, 18071 Granada, Spain. E-mail: jjoh{at}ugr.es

This study investigates aging-related changes in lipid peroxidation and functionality in liver and skeletal-muscle mitochondria in rats fed a diet rich in polyunsaturated fatty acids (PUFA), depending on supplementation or not with coenzyme Q10 (CoQ10). Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with CoQ10. At 6 and 24 months mitochondria were analyzed for fatty acid profile; hydroperoxides; {alpha}-tocopherol; CoQ9; CoQ10; cytochromes b, c+c1, and a+a3 contents; cytochrome c oxidase activity; and catalase activity in cytosol. Results of this study showed for the supplemented group an age-associated decrease in the peroxidizability index, an increase in catalase activity in skeletal muscle, and modulation of the aging-related changes in different mitochondrial electron-transport-chain components in skeletal muscle. These findings provide mechanisms to explain the effect of CoQ10 in extending the life span of animals fed a PUFA-rich diet.







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