Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flurkey, K.
Right arrow Articles by Harrison, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flurkey, K.
Right arrow Articles by Harrison, D. E.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62:1187-1198 (2007)
© 2007 The Gerontological Society of America

PohnB6F1: A Cross of Wild and Domestic Mice That Is a New Model of Extended Female Reproductive Life Span

Kevin Flurkey, Yaniv Brandvain, Simon Klebanov, Steven N. Austad, Richard A. Miller, Rong Yuan and David E. Harrison

1 The Jackson Laboratory, Bar Harbor, Maine.
2 College of the Atlantic, Bar Harbor, Maine.
3 University of Texas Health Science Center, Barshop Institute for Longevity and Aging Study, San Antonio.
4 University of Michigan Geriatrics Center, Ann Arbor.

Address correspondence to David E. Harrison, PhD, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609. E-mail: david.harrison{at}jax.org

In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans—mean age at last litter of 647 ± 32 days—longer than for the parental strains (70% longer than Pohn, 88% longer than B6) and longer than for highly heterogeneous crosses of laboratory mice. Litter size among young PohnB6F1 adults was similar to parental stocks, but their age-related decline in litter size was delayed by 150–200 days, resembling the earlier Pohn generations. Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2007 by The Gerontological Society of America.