HomeLarge Type Edition
HOME ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
PubMed
Right arrow PubMed Citation
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62:9-17 (2007)
© 2007 The Gerontological Society of America

Impaired Expression of Notch Signaling Genes in Aged Human Skeletal Muscle

Kate A. Carey, Michelle M. Farnfield, Sarah D. Tarquinio and David Cameron-Smith

School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.

Address correspondence to David Cameron-Smith, PhD, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway. Burwood, Victoria 3125, Australia. E-mail: david.cameron-smith{at}deakin.edu.au

Notch signaling is essential for myogenesis and the regenerative potential of skeletal muscle; however, its regulation in human muscle is yet to be fully characterized. Increased expression of Notch3, Jagged1, Hes1, and Hes6 gene transcripts were observed during differentiation of cultured human skeletal muscle cells. Furthermore, significantly lower expressions of Notch1, Jagged1, Numb, and Delta-like 1 were evident in muscle biopsies from older men (60–75 years old) compared to muscle from younger men (18–25 years old). Importantly, with supervised resistance exercise training, expression of Notch1 and Hes6 genes were increased and Delta-like 1 and Numb expression were decreased. The differences in Notch expression between the age groups were no longer evident following training. These results provide further evidence to support the role of Notch in the impaired regulation of muscle mass with age and suggest that some of the benefits provided by resistance training may be mediated through the Notch signaling pathway.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. Suetta, L. G. Hvid, L. Justesen, U. Christensen, K. Neergaard, L. Simonsen, N. Ortenblad, S. P. Magnusson, M. Kjaer, and P. Aagaard
Effects of aging on human skeletal muscle after immobilization and retraining
J Appl Physiol, October 1, 2009; 107(4): 1172 - 1180.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
G.-R. Dou, Y.-C. Wang, X.-B. Hu, L.-H. Hou, C.-M. Wang, J.-F. Xu, Y.-S. Wang, Y.-M. Liang, L.-B. Yao, A.-G. Yang, et al.
RBP-J, the transcription factor downstream of Notch receptors, is essential for the maintenance of vascular homeostasis in adult mice
FASEB J, May 1, 2008; 22(5): 1606 - 1617.
[Abstract] [Full Text] [PDF]


HOME ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by The Gerontological Society of America.