| HOME | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|---|
| ||||||||||||||||||||||||||||||||
1 Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Berne, Switzerland.
2 Department of Psychiatry, University of California San Diego, La Jolla.
3 Veterans Affairs San Diego Healthcare System, La Jolla, California.
Address correspondence to Igor Grant, MD, Department of Psychiatry, University of California, 9500 Gilman Drive, La Jolla, CA 92093-0680. E-mail: igrant{at}ucsd.edu
Background. Elevated plasma levels of interleukin (IL)-6, C-reactive protein (CRP), and D-dimer belong to the biological alterations of the "frailty syndrome," defining increased vulnerability for diseases and mortality with aging. We hypothesized that, compatible with premature frailty, chronic stress and age are related in predicting inflammation and coagulation activity in Alzheimer caregivers.
Methods. Plasma IL-6, CRP, and D-dimer levels were measured in 170 individuals (mean age 73 ± 9 years; 116 caregivers, 54 noncaregiving controls). Demographic factors, diseases, drugs, and lifestyle variables potentially affecting inflammation and coagulation were obtained by history and adjusted for as covariates in statistical analyses.
Results. Caregivers had higher mean levels of IL-6 (1.38 ± 1.42 vs 1.00 ± 0.92 pg/mL, p =.032) and of D-dimer (723 ± 530 vs 471 ± 211 ng/mL, p <.001) than controls had. CRP levels were similar between groups (p =.44). The relationship between caregiver status and D-dimer was independent of covariates (p =.037) but affected by role overload. Age accounted for much of the relationship with IL-6. After controlling for covariates, the interaction between caregiver status and age was significant for D-dimer (ß =.20, p =.029) and of borderline significance for IL-6 (ß =.17, p =.090). Post hoc regression analyses indicated that, among caregivers, age was significantly correlated with both D-dimer (ß =.50, p <.001) and IL-6 (ß =.38, p =.001). Among controls, however, no significant relationship was observed between age and either D-dimer or IL-6.
Conclusions. The interaction between caregiving status and age for D-dimer and IL-6 suggests the possibility that older caregivers could be at risk of a more rapid transition to the frailty syndrome and clinical manifestations of cardiovascular diseases.
This article has been cited by other articles:
 |
|
 |
|
  M. Devor and M. Renvall An Educational Intervention to Support Caregivers of Elders With Dementia American Journal of Alzheimer's Disease and Other Dementias, June 1, 2008; 23(3): 233 - 241. [Abstract] [PDF]
|
|
|
|
 |
|
 S. W. Williams, C. S. Williams, S. Zimmerman, J. Munn, D. Dobbs, and P. D. Sloane Emotional and Physical Health of Informal Caregivers of Residents at the End of Life: The Role of Social Support J. Gerontol. B. Psychol. Sci. Soc. Sci., May 1, 2008; 63(3): S171 - S183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Wirtz, L. S. Redwine, C. Baertschi, M. Spillmann, U. Ehlert, and R. von Kanel Coagulation Activity Before and After Acute Psychosocial Stress Increases With Age Psychosom Med, May 1, 2008; 70(4): 476 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. T. Mausbach, R. von Kanel, K. Aschbacher, S. K. Roepke, J. E. Dimsdale, M. G. Ziegler, P. J. Mills, T. L. Patterson, S. Ancoli-Israel, and I. Grant Spousal Caregivers of Patients With Alzheimer's Disease Show Longitudinal Increases in Plasma Level of Tissue-Type Plasminogen Activator Antigen Psychosom Med, October 1, 2007; 69(8): 816 - 822. [Abstract] [Full Text] [PDF]
|
|
| HOME | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|---|
