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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61:562-567 (2006)
© 2006 The Gerontological Society of America

Long-Lived Growth Hormone Receptor Knockout Mice Show a Delay in Age-Related Changes of Body Composition and Bone Characteristics

Michael S. Bonkowski, Richard W. Pamenter, Juliana S. Rocha, Michal M. Masternak, Jacob A. Panici and Andrzej Bartke

Departments of 1 Physiology and Internal Medicine-Geriatrics Research, 2 Pharmacology, 3 Internal Medicine-Endocrinology and Metabolism, 4 Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield.
5 Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte MG, Brazil.

Address correspondence to Michael S. Bonkowski, MS, Southern Illinois University, School of Medicine, Geriatrics Research, Department of Internal Medicine, 1801 N. Rutledge St., Room 4389, P.O. Box 19628, Springfield, IL 62794-9628. E-mail: mbonkowski{at}siumed.edu

There is conflicting information on the physiological role of growth hormone (GH) in the control of aging. This study reports dual-energy x-ray absorptiometry (DXA) measurements of body composition and bone characteristics in young, adult, and aged long-lived GH receptor knockout (GHR-KO) and normal mice to determine the effects of GH resistance during aging. Compared to controls, GHR-KO mice showed an increased percentage of body fat. GHR-KO mice have reduced total-body bone mineral density (BMD), bone mineral content, and bone area, but these parameters increased with age. In addition, GHR-KO mice have decreased femur length, femur BMD, and lower lumbar BMD compared to controls in all age groups. These parameters also continued to increase with age. Our results indicate that GH resistance alters body composition, bone growth, and bone maintenance during aging in GHR-KO mice.




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J. F. Giani, M. S. Bonkowski, M. C. Munoz, M. M. Masternak, D. Turyn, A. Bartke, and F. P. Dominici
Insulin Signaling Cascade in the Hearts of Long-Lived Growth Hormone Receptor Knockout Mice: Effects of Calorie Restriction
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2008; 63(8): 788 - 797.
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Copyright © 2006 by The Gerontological Society of America.