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Effects of Caloric Restriction and Exercise on Age-Related, Chronic Inflammation Assessed by C-Reactive Protein and Interleukin-6

Department of Aging and Geriatric Research, Biochemistry of Aging Laboratory, Institute on Aging, and College of Medicine, University of Florida, Gainesville.

Address correspondence to Christiaan Leeuwenburgh, PhD, College of Medicine, Department of Aging and Geriatric Research, University of Florida Institute on Aging, Genomics and Biomarker Core of the Institute on Aging, Biochemistry of Aging Laboratory, 1329 SW 16th Street, Room 5263, P.O. Box 100107, Gainesville, FL 32608. E-mail: cleeuwen{at}aging.ufl.edu

Chronic inflammation is associated with the aging process and numerous age-related pathologies. We evaluated the effects of age, caloric restriction (CR), and exercise on plasma C-reactive protein (CRP), interleukin-6, and total antioxidant capacity in Fisher 344 rats. The inflammatory markers were analyzed using enzyme-linked immunosorbent assays (ELISA), while total antioxidant potential was determined by a spectrophotometric method. An increase in circulating levels of CRP with age was attenuated with long-term 40% CR; short-term 40% CR in young animals also reduced CRP concentration compared to age-matched controls. Lifelong exercise with 8% CR showed a marked decrease in CRP levels compared to 8% CR controls and an even greater reduction compared to ad libitum-fed rats. Plasma interleukin-6 levels remained unchanged with age, CR, and exercise, whereas inflammation levels showed an inverse association with plasma antioxidant status. These studies highlight the anti-inflammatory effects of CR and exercise.

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