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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:1190-1201 (2005)
© 2005 The Gerontological Society of America

REVIEW ARTICLE

The Role of Homocysteine in Multisystem Age-Related Problems: A Systematic Review

Hsu-Ko Kuo1,2,6,7, Farzaneh A. Sorond1,2,3,6, Jen-Hau Chen1,2,6,7, Ardeshir Hashmi1,2, William P. Milberg4,5,6 and Lewis A. Lipsitz1,2,6,

1 Hebrew Rehabilitation Center for Aged, Boston, Massachusetts.
2 Beth Israel Deaconess Medical Center, Boston, Massachusetts.
3 Brigham and Women's Hospital, Boston, Massachusetts.
4 Geriatric Neuropsychology Laboratory, Geriatric, Research, Education and Clinical Center (GRECC), Brockton/West Roxbury Department of Veterans Affairs Medical Center, Boston, Massachusetts.
5 Department of Psychiatry
6 Division of Aging, Harvard Medical School, Boston, Massachusetts.
7 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Address correspondence to Lewis A. Lipsitz, MD, Hebrew Rehabilitation Center for Aged, 1200 Centre Street, Boston, MA 02131. E-mail: lipsitz{at}mail.hrca.harvard.edu

Homocysteine is a sulfur-containing amino acid that is involved in one-carbon metabolism. Hyperhomocysteinemia is a common phenomenon among elderly people. There is growing evidence of an association between hyperhomocysteinemia and geriatric multisystem problems, including coronary artery disease, stroke, peripheral vascular disease, cognitive impairment, dementia, depression, osteoporotic fractures, and functional decline. The proposed mechanisms of the association include angiotoxicity, neurotoxicity, and inhibition of collagen cross-linking. A homocysteine-lowering strategy may prevent or slow the development of these age-related problems. Vitamin supplementation and folic acid fortification of grain foods have been shown to decrease plasma homocysteine concentrations. More research is needed to investigate whether lifelong homocysteine lowering can prevent the development of late-life morbidity.




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