Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Forsyth, C. B.
Right arrow Articles by Loeser, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Forsyth, C. B.
Right arrow Articles by Loeser, R. F., Jr
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:1118-1124 (2005)
© 2005 The Gerontological Society of America

Increased Matrix Metalloproteinase-13 Production With Aging by Human Articular Chondrocytes in Response to Catabolic Stimuli

Christopher B. Forsyth1, Ada Cole2, Gillian Murphy3, Julia L. Bienias1, Hee-Jeong Im1,2 and Richard F. Loeser, Jr1,2,

1 Departments of Internal Medicine
2 Biochemistry, Rush Medical College, Rush University Medical Center, Chicago, Illinois.
3 Cambridge Institute for Medical Research, Department of Oncology, University of Cambridge, United Kingdom.

Address correspondence to Richard F. Loeser, Jr., MD, Chief, Section of Molecular Medicine, The Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157. E-mail: rloeser{at}wfubmc.edu

Chondrocyte anabolic activity has been shown to decline with aging, but catabolic activity has received little attention. In this study, the effect of aging on the chondrocyte catabolic response was determined by stimulating isolated human chondrocytes with fibronectin fragments (FN-f) or interleukin-1ß and measuring matrix metalloproteinase-13 (MMP-13) production as a catabolic response. A significant age-related increase in chondrocyte MMP-13 production was noted. FN-f stimulation of MMP-13 expression was blocked using a nuclear factor kappa-B (NF{kappa}B) inhibitor suggesting a role for NF{kappa}B in this chondrocyte catabolic response. Chondrocyte production of the NF{kappa}B-regulated cytokine interleukin-1ß was also found to increase with donor age in unstimulated cells. These results demonstrate a significant age-related increase in chondrocyte catabolic responsiveness which could contribute to the development of osteoarthritis in older adults.




This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
D Iliopoulos, K N Malizos, and A Tsezou
Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention
Ann Rheum Dis, December 1, 2007; 66(12): 1616 - 1621.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
R Ahmad, H Y Qureshi, M El Mabrouk, J Sylvester, M Ahmad, and M Zafarullah
Inhibition of interleukin 1-induced matrix metalloproteinase 13 expression in human chondrocytes by interferon {gamma}
Ann Rheum Dis, June 1, 2007; 66(6): 782 - 789.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2005 by The Gerontological Society of America.