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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:970-975 (2005)
© 2005 The Gerontological Society of America

Coenzyme Q10 Protects From Aging-Related Oxidative Stress and Improves Mitochondrial Function in Heart of Rats Fed a Polyunsaturated Fatty Acid (PUFA)-Rich Diet

Julio J. Ochoa, José L. Quiles, Jesús R. Huertas and José Mataix

Institute of Nutrition and Food Technology, Department of Physiology, University of Granada, Spain.

Address correspondence to Dr. Julio J. Ochoa, Institute of Nutrition and Food Technology, C/Ramón y Cajal, 4, 18071 Granada, Spain. E-mail: jjoh{at}ugr.es

Coenzyme Q10 supplementation on age-related changes in oxidative stress and function of heart mitochondria in rats fed a polyunsaturated fatty acid (PUFA)-rich diet was investigated. Two groups of rats were fed for 24 months on a PUFA-rich diet, differing in supplementation or not with coenzyme Q10. Animals were killed at 6, 12, or 24 months. Fatty-acid profile, hydroperoxides, {alpha}-tocopherol, coenzyme Q, catalase and glutathione peroxidase activities, and cytochromes a+a3, b, c+c1 and cytochrome c oxidase activity were measured. Coenzyme Q10-supplemented animals showed lower hydroperoxide levels; higher content and/or activity of {alpha}-tocopherol, coenzyme Q, and catalase; and a slightly lower decrease in mitochondrial function. According to that, previously reported positive effects of coenzyme Q supplementation on the life span of rats fed a PUFA-rich diet might be a consequence, at least in part, of a lower oxidative stress level and perhaps, to a minor extent, of a smaller decrease in mitochondrial function.




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Copyright © 2005 by The Gerontological Society of America.