HomeLarge Type Edition
HOME ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
PubMed
Right arrow PubMed Citation
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:815-819 (2005)
© 2005 The Gerontological Society of America

Platelet Characteristics Change With Aging: Role of Estrogen Receptor ß

Muthuvel Jayachandran1,2, Krzysztof Karnicki3, Randall S. Miller3, Whyte G. Owen3,4, Kenneth S. Korach5 and Virginia M. Miller1,2,

Departments of 1 Surgery
2 Physiology and Biophysics
3 Section of Hematology Research
4 Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota.
5 National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

Address correspondence to Virginia M. Miller, PhD, Department of Surgery, Physiology and Biophysics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905. E-mail: miller.virginia{at}mayo.edu

Estrogen receptor beta (ßER) is the predominant estrogen receptor in platelets. Experiments were designed to define phenotypic changes in platelets with aging following deletion of ßER (ßERKO). Blood was collected from wild-type and ßERKO female mice at 4–7 (young) and 24–25 (aged) months of age. In young animals, total number of platelets, number of platelets containing RNA (reticulated platelets), aggregation, dense body adenosine triphosphate secretion, and alpha granular secretion were the same in both groups. With aging, total number of platelets decreased but reticulated platelets increased in ßERKO mice; aggregation and dense granule adenosine triphosphate secretion decreased whereas basal expression of fibrinogen receptors increased with age in wild-type and ßERKO mice. Basal expression of P-selectin and annexin V binding increased with aging only in ßERKO mice; thrombin did not increase expression in these mice. Therefore, deletion of ßER is associated with specific platelet functions, which are expressed only with age-associated reproductive senescence.




This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
V. M. Miller and S. P. Duckles
Vascular Actions of Estrogens: Functional Implications
Pharmacol. Rev., June 1, 2008; 60(2): 210 - 241.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Jayachandran, G. J. Brunn, K. Karnicki, R. S. Miller, W. G. Owen, and V. M. Miller
In vivo effects of lipopolysaccharide and TLR4 on platelet production and activity: implications for thrombotic risk
J Appl Physiol, January 1, 2007; 102(1): 429 - 433.
[Abstract] [Full Text] [PDF]


HOME ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by The Gerontological Society of America.