Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Karasik, D.
Right arrow Articles by Kiel, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Karasik, D.
Right arrow Articles by Kiel, D. P.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:574-587 (2005)
© 2005 The Gerontological Society of America

REVIEW ARTICLE

Disentangling the Genetic Determinants of Human Aging: Biological Age as an Alternative to the Use of Survival Measures

David Karasik1,, Serkalem Demissie2, L. Adrienne Cupples2 and Douglas P. Kiel1

1 Hebrew Rehabilitation Center for Aged and Harvard Medical School, Boston, Massachusetts.
2 Biostatistics, Boston University School of Public Health, Massachusetts.

Address correspondence to David Karasik, PhD, Hebrew Rehabilitation Center for Aged, Research and Training Institute, 1200 Centre Street, Boston, MA 02131. E-mail: karasik{at}mail.hrca.harvard.edu

The choice of a phenotype is critical for the study of a complex genetically regulated process, such as aging. To date, most of the twin and family studies have focused on broad survival measures, primarily age at death or exceptional longevity. However, on the basis of recent studies of twins and families, biological age has also been shown to have a strong genetic component, with heritability estimates ranging from 27% to 57%. The aim of this review is twofold: first, to summarize growing consensus on reliable methods of biological age assessment, and second, to demonstrate validity of this phenotype for research in the genetics of aging in humans.




This article has been cited by other articles:


Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
R. E. Ricklefs and C. D. Cadena
Heritability of Longevity in Captive Populations of Nondomesticated Mammals and Birds
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2008; 63(5): 435 - 446.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
K. Rockwood and A. Mitnitski
Frailty in Relation to the Accumulation of Deficits
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2007; 62(7): 722 - 727.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
T. M. Frayling, S. Rafiq, A. Murray, A. J. Hurst, M. N. Weedon, W. Henley, S. Bandinelli, A.-M. Corsi, L. Ferrucci, J. M. Guralnik, et al.
An Interleukin-18 Polymorphism Is Associated With Reduced Serum Concentrations and Better Physical Functioning in Older People
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2007; 62(1): 73 - 78.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2005 by The Gerontological Society of America.