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1 Department of Clinical Nutrition and Diets, Numico Research, Wageningen, The Netherlands.
2 Department of Clinical Neuropsychology, Free University, Amsterdam, The Netherlands.
3 Department of Human Nutrition and Epidemiology, Wageningen University, The Netherlands.
Address correspondence to W. Wouters-Wesseling, DMV Nutritionals, 40196 State Highway 10, Delhi, NY 13753. E-mail: wendeline.wouters{at}dmv-ny.com
Background. Many elderly persons report that they have difficulties learning new things and remembering names, plans, and conversations. Because decreased cognitive function in elderly persons is potentially related to their poor nutritional status, provision of essential nutrients may improve cognitive function. The authors wanted to determine whether consumption of an enriched drink, including moderate doses of all essential micronutrients, improves cognitive function in frail elderly persons.
Methods. Frail, white adults (n = 101) who were aged 65 years or older with a body mass index 
25 kg/m2 were selected for this randomized, double-blind, placebo-controlled trial. They received either an enriched drink or a placebo product for 6 months. Before and after the intervention, participants' cognitive function was assessed (word learning test [WLT], WLT delayed, category fluency [CF] for animals and professions, and recognition memory test for words [RMTW]) and blood biochemical analyses (vitamin B12, homocysteine) were performed.
Results. Sixty-seven residents completed the study period. After 6 months, significant differences were noted in changes of the WLT (0.9 ± 0.3 vs –0.1 ± 0.3; p =.014) and CF professions (1.2 ± 0.7 vs –0.6 ± 0.5; p =.017) in the supplement group (n = 34) compared with the placebo group (n = 33). No significant differences were observed in WLT delayed, RMTW, and CF animals. The plasma vitamin B12 concentration increased (105 ± 50 vs 8 ± 16; p =.003) and the homocysteine concentration decreased (–6.3 ± 5.9 vs –0.3 ± 2.9; p =.000) in the supplement group compared with the placebo group.
Conclusions. This study contributes to the evidence that nutritional supplementation may improve neuropsychological performance in frail elderly persons.
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