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1 Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio.
Departments of 2 Cellular & Structural Biology, 3 Physiology, 4 Pharmacology, and the 5 Barshop Center for Longevity and Aging Studies at The University of Texas Health Science Center at San Antonio.
6 Department of Laboratory Animal Medicine, Southwest Foundation for Biomedical Research, San Antonio, Texas.
Address correspondence to James F. Nelson, PhD, Department of Physiology, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229. E-mail: nelsonj{at}uthscsa.edu
This study examined the effect of housing density on the longevity-extending and disease-delaying actions of calorie restriction (CR). Singly or multiply housed (four per cage) mice were either fed ad libitum (AL) or were on CR beginning at 2 months. All CR mice were fed 40% less food than were multiply housed AL mice. CR increased median longevity by 19%, and housing density had no effect on this increase. CR also reduced neoplastic lesions in both housing groups, but lymphoma, the most common neoplasm, was reduced more in singly than in multiply housed mice. Singly housed AL mice ate 40% more food than did multiply housed AL mice, but weighed the same and lived as long as multiply housed AL mice. These results indicate that CR can extend life span as effectively in multiply as in singly housed mice, even though housing density can differentially affect the cancer-reducing effect of CR.
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