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1 Department of Health and Human Performance, University of Houston, Texas.
2 Health and Kinesiology, Purdue University, West Lafayette, Indiana.
3 Department of Kinesiology, Texas Christian University, Fort Worth.
Address correspondence to Brian K. McFarlin, PhD, University of Houston, Department of Health and Human Performance, 3855 Holman St., 104U Garrison, Houston, Texas 77204-6015. E-mail: bmcfarlin{at}uh.edu
Background. Regular exercise has been reported to slow the age-associated declines in natural killer cell activity (NKCA). To evaluate this response, we recruited older, postmenopausal women (65–85 years old) to fill one of two groups: training (10 weeks of resistance exercise; TR) or control.
Methods. Blood samples were collected from an arm vein in the TR group at rest (PRE), immediately following (POST), and 2 hours (2H) following an acute bout of resistance exercise both before (BEFORE) and after (AFTER) training. Leukocytes and NKCA were determined by flow cytometry and a whole blood 51Cr release assay, respectively.
Results. Acute exercise increased total leukocyte (p <.05), CD8 (p <.05), CD4 (p <.05), and CD56 counts (p <.05), but there was no effect of training. NKCA was greater TR-AFTER-PRE (136%), -POST (80%), and -2H (127%) compared to similar values from TR-BEFORE (p <.05).
Conclusion. Increased resting NKCA after chronic resistance training suggests that immunity has been improved.
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