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Aging: The Reality

Biomarkers of Aging: From Primitive Organisms to Humans

¹ International Longevity Center-USA, New York.
² The Ellison Medical Foundation, Bethesda, Maryland.
³ Biology of Aging Program, National Institute on Aging, Bethesda, Maryland.
⁴ Metagenics, Inc., Gig Harbor, Washington.
⁵ National Center for Toxicology Research, Jefferson, Arkansas.
⁶ Texas College of Osteopathic Medicine, Fort Worth.
⁷ The Institute for the Study of Aging, New York.
⁸ Kronos Longevity Research Institute, Phoenix, Arizona.
⁹ Canyon Ranch Health Resort, Tucson, Arizona.
¹⁰ Canyon Ranch in the Berkshires, Lenox, Massachusetts.
¹¹ Desert Life Medical Plaza, Tucson, Arizona.
¹² Penn State University, College of Health and Human Development, University Park, Pennsylvania.
¹³ The University of Texas, San Antonio.
¹⁴ The University of Texas, Health Science Center, San Antonio.
¹⁵ Department of Physiology/Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
¹⁶ University of Wisconsin, Madison.
¹⁷ University of Washington, Seattle.

Address correspondence to Robert N. Butler, International Longevity Center-USA, 60 E. 86th St., New York, NY 10028. E-mail: robertb{at}ilcusa.org

Leading biologists and clinicians interested in aging convened to discuss biomarkers of aging. The goals were to come to a consensus, construct an agenda for future research, and make appropriate recommendations to policy makers and the public-at-large. While there was not total agreement on all issues, they addressed a number of questions, among them whether biomarkers can be identified and used to measure the physiological age of any individual within a population, given emerging information about aging and new technological advances. The hurdles to establishing informative biomarkers include the biological variation between individuals that makes generalizations difficult; the overlapping of aging and disease processes; uncertainty regarding benign versus pathogenic age-related changes; the point at which a process begins to do damage to the organism, and, if so, when does it occur; and when to distinguish critical damage from noncritical damage. Finally, and significantly, it is difficult to obtain funding for this research.

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