Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59:B227-B232 (2004)
© 2004 The Gerontological Society of America

Genome-Wide Scan for a Healthy Aging Phenotype Provides Support for a Locus Near D4S1564 Promoting Healthy Aging

Terry Reed1,, Danielle M. Dick1, Sean K. Uniacke2, Tatiana Foroud1 and William C. Nichols2

1 Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis.
2 Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Ohio.

Address correspondence to Dr. Terry Reed, Department of Medical & Molecular Genetics, IB 130, 975 West Walnut St., Indianapolis, IN 46202-5251. E-mail: treed{at}iupui.edu

Living to a late age without suffering any major health problems is a genetically influenced trait. To identify the genes contributing to this important phenotype, a 10 cM genome screen was performed in 95 pairs of male fraternal twins concordant for healthy aging. Individuals meeting these criteria were defined as those attaining the age of 70 free of cardiovascular disease (coronary surgery, diabetes, heart attack, and stroke) and prostate cancer. Six chromosomal regions were identified with logarithm of odds (LOD) scores greater than 1.2 (p <.01). A region on chromosome 4 at marker D4S1564 produced a LOD score of 1.67; this was the same marker previously linked to extreme longevity segregating as an autosomal dominant trait in centenarian families. Our results provide independent evidence that a locus on the long arm of chromosome 4 is associated with better physical aging and/or longevity.




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D. Karasik, S. Demissie, L. A. Cupples, and D. P. Kiel
Disentangling the Genetic Determinants of Human Aging: Biological Age as an Alternative to the Use of Survival Measures
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 574 - 587.
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