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Mapping Development-Related and Age-Related Chromatin Remodeling by a High Throughput ChIP-HPLC Approach

National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Address correspondence to Bruce Howard, MD, National Institute for Child Health and Human Development, NIH, Bldg. 31, Rm. 2A25, 6 Center Dr., Bethesda, MD 20892. E-mail: howard{at}helix.nih.gov

Common to numerous differentiation pathways in vertebrate organisms is the regulation of key genes through epigenetic mechanisms. Less well studied is to what extent cells of a given differentiation state, but examined at different points within the life history of an organism, are distinct at the level of the epigenome. A few instances of such variation have been reported, and it would be of considerable value to have at hand a means to characterize additional examples more efficiently. We describe an integrated approach to this task, and further present evidence for regions of age-related histone H4 acetylation change extending over tens to hundreds of kilobases. Broad similarity between two distinct regions of such change suggests a previously unsuspected link between developmental programs and aging.

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