|
|
||||||||
1 Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
2 Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park.
3 Clinical Research Branch, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland.
We studied the association of the G-174C promoter polymorphism in the interleukin-6 gene (IL6) with total body fat and fat-free mass (FFM) in 242 men and women (IL6 genotypes: G/G, n = 87; G/C, n = 100; C/C, n = 55) across the adult age span (2192 years). In men, but not women (significant genotype by sex interactions; p =.023.048), the C/C group exhibited significantly lower total FFM than the G/G group (54.7 ± 0.8 kg vs 57.2 ± 0.7 kg, respectively, p =.020), as well as significantly lower FFM of the lower limbs compared with the G/G group (18.4 ± 0.3 kg vs 19.8 ± 0.3 kg, respectively, p =.004). No significant genotype differences were observed in total body fat mass in either men or women. The results indicate that the IL6 G-174C polymorphism is significantly associated with FFM in men but not women.
This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)
|
T. Rankinen, A. Zuberi, Y. C. Chagnon, S. J. Weisnagel, G. Argyropoulos, B. Walts, L. Perusse, and C. Bouchard The Human Obesity Gene Map: The 2005 Update Obesity, April 1, 2006; 14(4): 529 - 644. [Abstract] [Full Text] [PDF] |
||||
|
J Cockerill, S Uthaya, C J Dore, and N Modi Accelerated postnatal head growth follows preterm birth Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2006; 91(3): F184 - F187. [Abstract] [Full Text] [PDF] |
||||
|
B. J. Nicklas, J. Mychaleckyj, S. Kritchevsky, S. Palla, L. A. Lange, E. M. Lange, S. P. Messier, D. Bowden, and M. Pahor Physical Function and Its Response to Exercise: Associations With Cytokine Gene Variation in Older Adults With Knee Osteoarthritis J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2005; 60(10): 1292 - 1298. [Abstract] [Full Text] [PDF] |
||||
|
L. Perusse, T. Rankinen, A. Zuberi, Y. C. Chagnon, S. J. Weisnagel, G. Argyropoulos, B. Walts, E. E. Snyder, and C. Bouchard The Human Obesity Gene Map: The 2004 Update Obesity, March 1, 2005; 13(3): 381 - 490. [Abstract] [Full Text] [PDF] |
||||
|
R. A Dennis, T. A Trappe, P. Simpson, C. Carroll, B. E. Huang, R. Nagarajan, E. Bearden, C. Gurley, G. W Duff, W. J Evans, K. Kornman, and C. A Peterson Interleukin-1 polymorphisms are associated with the inflammatory response in human muscle to acute resistance exercise J. Physiol., November 1, 2004; 560(3): 617 - 626. [Abstract] [Full Text] [PDF] |
||||
HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
---|
All GSA journals | The Gerontologist |
Journals of Gerontology Series B: Psychological Sciences and Social Sciences |