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Interleukin-6 (IL6) Genotype Is Associated With Fat-Free Mass in Men But Not Women

¹ Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
² Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park.
³ Clinical Research Branch, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland.

We studied the association of the G-174C promoter polymorphism in the interleukin-6 gene (IL6) with total body fat and fat-free mass (FFM) in 242 men and women (IL6 genotypes: G/G, n = 87; G/C, n = 100; C/C, n = 55) across the adult age span (21–92 years). In men, but not women (significant genotype by sex interactions; p =.023–.048), the C/C group exhibited significantly lower total FFM than the G/G group (54.7 ± 0.8 kg vs 57.2 ± 0.7 kg, respectively, p =.020), as well as significantly lower FFM of the lower limbs compared with the G/G group (18.4 ± 0.3 kg vs 19.8 ± 0.3 kg, respectively, p =.004). No significant genotype differences were observed in total body fat mass in either men or women. The results indicate that the IL6 G-174C polymorphism is significantly associated with FFM in men but not women.

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