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Age-Associated Cardiomyopathy in Heterozygous Carrier Mice of a Pathological Mutation of Carnitine Transporter Gene, OCTN2

^a Departments of Hygiene, Akita University School of Medicine, Japan
^b Departments of Pathology 2, Akita University School of Medicine, Japan
^c Departments of Biochemistry, Akita University School of Medicine, Japan
^d Department of Hygiene, Hyogo College of Medicine, Nishinomiya, Japan
^e Institute for Experimental Animals, Faculty of Medicine, Kanazawa University, Japan
^f Department of Health and Environmental Sciences, Kyoto University School of Public Health, Japan

Akio Koizumi, Department of Health and Environmental Sciences, Kyoto University School of Public Health, Kyoto 606-8501, Japan E-mail: koizumi{at}pbh.med.kyoto-u.ac.jp.

Decision Editor: John A. Faulkner, PhD

The purpose of this study was to test whether heterozygotes of juvenile visceral steatosis mice, a model for systemic carnitine deficiency, may develop age-associated cardiomyopathy. Tissue morphological observations were carried out by light and electron microscopy to compare the heterozygous and age-matched control mice at periods of 1 and 2 years. Possible effects of the pathological mutation on lipid and glucose levels was also evaluated in humans and mice. Except mild increases in serum cholesterol levels in male heterozygous mice and humans, no changes were found in other factors, indicating that none of the confounding factors seems to be profound. Results demonstrated that heterozygous mice had larger left ventriclular myocyte diameters than the control mice. Morphological changes in cardiac muscles by electron microscopy revealed age-associated changes of lipid deposition and abnormal mitochondria in heterozygous mice. Two out of 60 heterozygous cohort and one out of nine heterozygous trim-kill mice had cardiac hypertrophy at ages older than 2 years. The present study and our previous work suggest that the carrier state of OCTN2 pathological mutations might be a risk factor for age-associated cardiomyopathy.

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