HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Cited by other online articles Google Scholar Articles by Scopacasa, F. Articles by Nordin, B.E.C. Articles citing this Article PubMed PubMed Citation Articles by Scopacasa, F. Articles by Nordin, B.E.C.

Bone Density and Bone-Related Biochemical Variables in Normal Men

A Longitudinal Study

^a Department of Medicine, University of Adelaide, South Australia, Australia
^b Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia

F. Scopacasa, Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia E-mail: franca.scopacasa{at}adelaide.edu.au.

Background. The objective of this study was to determine the pattern of forearm bone loss and its relationship to markers of bone turnover and sex steroids in normal men. This was a longitudinal study over a median interval of 41 months. The study was conducted in Adelaide, Australia. Study participants were 123 healthy male subjects, between the ages of 20 and 83 years.

Methods. Fat-corrected forearm bone mineral content (fcBMC), markers of bone formation (alkaline phosphatase, osteocalcin, procollagen type 1 C-terminal extension peptide) and bone resorption (collagen type I cross-linked telopeptide, hydroxyproline/creatinine, pyridinoline/creatinine, and deoxypyridinoline/creatinine), calculated serum bioavailable testosterone, and serum estradiol were measured.

Results. The mean time-weighted rate of change in forearm fcBMC was -0.33% ± 0.72 (SD) per year. Bone loss commenced after 30 years of age and increased with age (p < .001), particularly after age 70 years. There was no relationship between the rate of change in fcBMC and either markers of bone turnover or serum sex steroids.

Conclusions. In normal men, bone loss increases with age; there does not appear to be any relationship between this loss and either markers of bone turnover or levels of free androgen or estrogen.

This article has been cited by other articles: (Search Google Scholar for Other Citing Articles)

				N. Emaus, G. K. R. Berntsen, R. M. Joakimsen, and V. Fonnebo Longitudinal Changes in Forearm Bone Mineral Density in Women and Men Aged 25-44 Years: The Tromso Study: A Population-based Study Am. J. Epidemiol., October 1, 2005; 162(7): 633 - 643. [Abstract] [Full Text] [PDF]