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Effect of Age on Skeletal Muscle Proteolysis in Extensor Digitorum Longus Muscles of B6C3F1 Mice

^a Division of Geriatric Medicine, University of Michigan, and Veteran Affairs Ann Arbor Health Care System, Ann Arbor

Thomas H. Reynolds IV, Department of Pharmacology, 1300 Jefferson Park Avenue, University of Virginia Health System, P.O. Box 800735, Charlottesville, VA 22908-0735 E-mail: thr2n{at}virginia.edu.

Decision Editor: Edward Masoro, PhD

The purpose of this study was to determine if age-related muscle atrophy is associated with an increased rate of protein degradation in extensor digitorum longus (EDL) muscles from young (YG; 2–4 months), middle-aged (MA; 12–17 months), and aged (AG; 22–24 months) B6C3F1 mice. EDL muscles from AG mice weighed less than EDL muscles from MA mice (p = .01). EDL muscles from MA mice weighed more than EDL muscles from YG mice (p = .02). The rate of protein degradation, as assessed by tyrosine release during in vitro incubations, was higher in EDL muscles from AG mice than it was in those from MA mice (p = .03). The rate of protein degradation was higher in EDL muscles from YG mice than it was in those from MA mice (p = .04). An inverse relationship existed between muscle mass and protein degradation (r = -.67; p = .0001). We conclude that skeletal muscle protein degradation rates decrease with maturation and increase with advancing age.

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