Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kerber, R. A.
Right arrow Articles by Cawthon, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kerber, R. A.
Right arrow Articles by Cawthon, R. M.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 56:B130-B139 (2001)
© 2001 The Gerontological Society of America

Familial Excess Longevity in Utah Genealogies

Richard A. Kerbera,b, Elizabeth O'Brienb, Ken R. Smithb,c and Richard M. Cawthond

a Department of Oncological Sciences, University of Utah, Salt Lake City
b Huntsman Cancer Institute, University of Utah, Salt Lake City
c Department of Family and Consumer Studies, University of Utah, Salt Lake City
d Department of Human Genetics, University of Utah, Salt Lake City

Richard M. Cawthon, University of Utah, Department of Human Genetics, 15 N. 2030 E. Street, Room 2100, Salt Lake City, UT 84112-5330 E-mail: rcawthon{at}genetics.utah.edu.

Decision Editor: John A. Faulkner, PhD

We evaluated the influence of family history on longevity by examining longevity in a cohort of 78,994 individuals drawn from the Utah Population Database (UPDB) who were born between 1870 and 1907, and lived to at least age 65. We examined Mendelian genetic and social modes of transmission of excess longevity (the difference between observed and expected longevity) by varying weighted kinship contributions over different classes of relatives. The genetic component of the variation in excess longevity measured as heritability, h2, was approximately 0.15 (95% confidence interval [CI] 0.12–0.18). Among siblings of probands who reached the 97th percentile of excess longevity (+14.8 years, currently age 95 for men and 97 for women), the relative risk of recurrence ({lambda}s) was 2.30 (95% CI 2.08–2.56). In sibships whose relatives were in the top 15% of the distribution for familial excess longevity, the value of {lambda}s increased substantially, indicating that considering the longevity of distant relatives may be helpful in the selection of families in which to identify genes influencing aging and longevity.




This article has been cited by other articles:


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
B. J. Willcox, D. C. Willcox, and L. Ferrucci
Secrets of Healthy Aging and Longevity From Exceptional Survivors Around the Globe: Lessons From Octogenarians to Supercentenarians
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2008; 63(11): 1181 - 1185.
[Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
B. J. Willcox, T. A. Donlon, Q. He, R. Chen, J. S. Grove, K. Yano, K. H. Masaki, D. C. Willcox, B. Rodriguez, and J. D. Curb
FOXO3A genotype is strongly associated with human longevity
PNAS, September 16, 2008; 105(37): 13987 - 13992.
[Abstract] [Full Text] [PDF]


Home page
Obstet GynecolHome page
A. O. Hammoud, M. Gibson, C. M. Peterson, R. A. Kerber, G. P. Mineau, and H. Hatasaka
Quantification of the Familial Contribution to Mullerian Anomalies
Obstet. Gynecol., February 1, 2008; 111(2): 378 - 384.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
T. Perls, I. V. Kohler, S. Andersen, E. Schoenhofen, J. Pennington, R. Young, D. Terry, and I. T. Elo
Survival of Parents and Siblings of Supercentenarians
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2007; 62(9): 1028 - 1034.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
E. O'Brien, R. Kerber, K. Smith, G. Mineau, K. Boucher, and D. L. Reed
Familial Mortality in the Utah Population Database: Characterizing a Human Aging Phenotype
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2007; 62(8): 803 - 812.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
G. Garibotti, K. R. Smith, R. A. Kerber, and K. M. Boucher
Longevity and Correlated Frailty in Multigenerational Families
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2006; 61(12): 1253 - 1261.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
B. J. Willcox, D. C. Willcox, Q. He, J. D. Curb, and M. Suzuki
Siblings of okinawan centenarians share lifelong mortality advantages.
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2006; 61(4): 345 - 354.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
P. F. McArdle, T. I. Pollin, J. R. O'Connell, J. D. Sorkin, R. Agarwala, A. A. Schaffer, E. A. Streeten, T. M. King, A. R. Shuldiner, and B. D. Mitchell
Does having children extend life span? A genealogical study of parity and longevity in the amish.
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2006; 61(2): 190 - 195.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
T. T. Perls, J. Wilmoth, R. Levenson, M. Drinkwater, M. Cohen, H. Bogan, E. Joyce, S. Brewster, L. Kunkel, and A. Puca
Life-long sustained mortality advantage of siblings of centenarians
PNAS, June 11, 2002; 99(12): 8442 - 8447.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All GSA journals The Gerontologist
Journals of Gerontology Series B: Psychological Sciences and Social Sciences
Copyright © 2001 by The Gerontological Society of America.