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Age-Associated Increase of 8-Hydroxydeoxyguanosine in Human Colorectal Tissue DNA

^a Departments of Environmental Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan
^b Departments of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
^c Departments of Environmental Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan

Hiroshi Kasai, Department of Environmental Oncology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyush, 807-8555 Japan E-mail: h-kasai{at}med.uoeh-u.ac.jp.

Decision Editor: Edward Masoro, PhD

To clarify the role of oxidative stress in aging of colorectal tissue, we analyzed the 8-hydroxydeoxyguanosine (8-OH-dG) levels in colorectal biopsy samples from normal tissue of patients with either colorectal cancer (n = 15) or benign colorectal polyps (n = 40). An age-associated increase of 8-OH-dG was observed (p = .002), although the 8-OH-dG levels were not significantly different between the patients with cancer and those with polyps. These results suggest an increased level of 8-OH-dG formation in human colorectal tissue with age.

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