Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 55:B415-B417 (2000)
© 2000 The Gerontological Society of America

Oxidative Stress Resistance

A Robust Correlated Response to Selection in Extended Longevity Lines of Drosophila melanogaster?

Lawrence G. Harshmana and Beth A. Haberera

a School of Biological Sciences, University of Nebraska–Lincoln

Lawrence G. Harshman, School of Biological Science, University of Nebraska\|[mdash ]\|Lincoln, Lincoln, NE 68588 E-mail: lharsh{at}unlserve.unl.edu.

Decision Editor: Jay Roberts, PhD

Stress resistance is associated with longevity in Drosophila melanogaster and other model organisms used for genetic research. The present study tests for oxidative stress resistance in one set of lines selected for late-life reproduction and extended longevity. Both females and males from the selected lines were appreciably more resistant to oxidative stress than were flies from the control lines. A relative increase in oxidative stress resistance is a correlated response to selection in this laboratory selection experiment. Increased oxidative stress resistance appears to be a relatively robust correlated response to laboratory selection for late-life reproduction and extended longevity.




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