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Effects of Age and Gender on Rat Upper Airway Muscle Contractile Properties

^a Department of Physiology, Royal College of Surgeons in Ireland, Dublin

Aidan Bradford, Department of Physiology, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.

Decision Editor: Jay Roberts, PhD

Upper airway muscles regulate upper airway patency. Obstructive sleep apnea is caused by upper airway collapse, and its incidence increases with age and is higher in men than women. The reasons for this are unknown, as little is known about the effects of age and gender on upper airway muscle. Isometric contractile properties were determined using strips of geniohyoid and sternohyoid muscles from young and old, male and female rats in physiological saline solution at 30°C. There were no differences between the male and female rats in any of the contractile properties of either muscle, and this was true for both young and old animals. Aging had no effect on sternohyoid contractile properties, but geniohyoid force was greater in old than in young rats.

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