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a Stockholm Gerontology Research Center, Division of Geriatric Medicine, Neurotec, Karolinska Institute, Stockholm, Sweden.
b IRCCS San Giovanni di Dio—FBF, Brescia, Italy
Giovanni B. Frisoni, Laboratory of Epidemiology \|[amp ]\| Neuroimaging, IRCCS San Giovanni di Dio\|[mdash ]\|FBF, via Pilastroni 1, I-25123 Brescia, Italy E-mail: frisoni{at}master.cci.unibs.it.
Decision Editor: William B. Ershler, MD
Background. The physical health correlates of mild cognitive impairment (MCI) in the older individual are poorly known. The aim of this study was to investigate the relationship between physical health and MCI with population data.
Methods. Subjects were 1,435 nondemented 75- to 95-year-old subjects. MCI was defined as scoring one standard deviation below age- and education-specific means on the Mini-Mental State Examination. MCI was consistently associated with indicators of poorer health in logistic regression models with adjustment for potential confounders.
Results. The adjusted odds ratios for those with two, three, four, or more somatic symptoms compared with those with one or no symptoms were 1.3 (95% confidence intervals 1.0 to 1.9) and 2.1 (1.2 to 4.5; p for 
); for those with poor self-rated health the odds ratio was 1.9 (1.4 to 2.6); for those with one, two, or more chronic diseases compared with those with no chronic diseases, the odds ratios were 1.3 (0.9 to 1.9) and 3.0 (1.2 to 7.6; p for 
); and for those dying during the 3-year follow-up period the odds ratio was 1.5 (1.1 to 2.2).
Conclusions. MCI is associated with poor physical health, leading to the hypothesis of a causal relationship between physical diseases and MCI in older populations.
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