Minireview: Mechanisms by Which the Metabolic Syndrome and Diabetes Impair Memory

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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 55:B228-B232 (2000)
© 2000 The Gerontological Society of America

Minireview

Mechanisms by Which the Metabolic Syndrome and Diabetes Impair Memory

Meena Kumari^a, Eric Brunner^a and Rebecca Fuhrer^a

^a International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London.

Meena Kumari, International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London, WC1 6BT, UK E-mail: m.kumari{at}public-health.ucl.ac.uk.

Decision Editor: Jay Roberts, PhD

Type 2 diabetes is associated with an increased risk of cognitivedysfunction. These effects seem particularly true for memoryfunctions. This article examines how diabetes and the biologicalchanges that occur with diabetes such as hyperglycemia, changesin insulin concentration, hypertension, and changes in lipidlevels might lead to these alterations in cognitive functioning,with an emphasis on the mechanisms leading to changes in memory.

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HOME	ARCHIVE	SEARCH	TABLE OF CONTENTS

				M. Kumari and M. Marmot Diabetes and cognitive function in a middle-aged cohort: Findings from the Whitehall II study Neurology, November 22, 2005; 65(10): 1597 - 1603. [Abstract] [Full Text] [PDF]

				A. M. Kanaya, E. Barrett-Connor, G. Gildengorin, and K. Yaffe Change in Cognitive Function by Glucose Tolerance Status in Older Adults: A 4-Year Prospective Study of the Rancho Bernardo Study Cohort Arch Intern Med, June 28, 2004; 164(12): 1327 - 1333. [Abstract] [Full Text] [PDF]

				J. E. Morley, H. M. Perry III, and D. K. Miller Editorial: Something About Frailty J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2002; 57(11): M698 - 704. [Full Text] [PDF]

				V. A. Freedman, H. Aykan, and L. G. Martin Aggregate Changes in Severe Cognitive Impairment Among Older Americans: 1993 and 1998 J. Gerontol. B. Psychol. Sci. Soc. Sci., March 1, 2001; 56(2): 100S - 111. [Abstract] [Full Text]