Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 55, Issue 1 B5-B9, Copyright © 2000 by The Gerontological Society of America

JOURNAL ARTICLE

Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice

TT Huang, EJ Carlson, AM Gillespie, Y Shi and CJ Epstein
Department of Pediatrics, University of California, San Francisco 94143- 0546, USA. tthuang@itsa.ucsf.edu

Oxidative damage has been implicated in the aging process and in a number of degenerative diseases. To investigate the role of oxygen radicals in the aging process in mammals, the life spans of transgenic mice on a CD-1 background expressing increased levels of CuZn superoxide dismutase (CuZnSOD), the enzyme that metabolizes superoxide radicals, were determined. Homozygous transgenic mice with a two- to five-fold elevation of CuZnSOD in various tissues showed a slight reduction of life span, whereas hemizygous mice with a 15- to 3-fold increase of CuZnSOD showed no difference in life span from that of the nontransgenic littermate controls. The results suggest that constitutive and ubiquitous overexpression of CuZnSOD alone is not sufficient to extend the life spans of transgenic mice.

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