| HOME | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|---|
| ||||||||||||||||||||||||||||||
Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 55, Issue 1 B49-B53, Copyright © 2000 by The Gerontological Society of America
TWIN STUDY |
D Carmelli, M Kelly-Hayes, PA Wolf, GE Swan, LM Jack, T Reed and JM Guralnik
Center for Health Sciences, SRI International, Menlo Park, California 94025, USA. doritc@unix.sri.com
Tests of balance, gait, and endurance were administered to 95 monozygotic (MZ) and 92 dizygotic (DZ), white male twins aged 68 to 79 years who had been born in the United States. Within-twin-pair correlations were calculated for each individual task and for an overall summary performance score. These were subjected to structural equation modeling to determine the contributions of genetic and environmental influences to individual differences in performance scores. MZ intraclass correlations were significant and greater than DZ correlations for the 8-foot walk and the repeated chair stands task, but not for the standing balance task. The heritability of the lower- extremity summary score was 57%, of which 39% was due to additive genetic effects and 18% due to nonadditive effects. In addition, we found that genetic influences contributed primarily to twin similarity in the poorest quartile of performance, whereas shared environmental influences contributed to twin similarity in the best quartile.
This article has been cited by other articles:
 |
|
 |
|
  N. S Hopkinson, K. W. Li, A. Kehoe, S. E Humphries, M. Roughton, J. Moxham, H. Montgomery, and M. I Polkey Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease Am. J. Clinical Nutrition, February 1, 2008; 87(2): 385 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Melzer, A. J. Hurst, and T. Frayling Genetic Variation and Human Aging: Progress and Prospects J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2007; 62(3): 301 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Frayling, S. Rafiq, A. Murray, A. J. Hurst, M. N. Weedon, W. Henley, S. Bandinelli, A.-M. Corsi, L. Ferrucci, J. M. Guralnik, et al. An Interleukin-18 Polymorphism Is Associated With Reduced Serum Concentrations and Better Physical Functioning in Older People J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2007; 62(1): 73 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ortega-Alonso, N. L. Pedersen, U. M. Kujala, S. Sipila, T. Tormakangas, J. Kaprio, M. Koskenvuo, and T. Rantanen A twin study on the heritability of walking ability among older women. J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2006; 61(10): 1082 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. El Haber, K. D. Hill, A.-M. T. Cassano, L. M. Paton, R. J. MacInnis, J. S. Cui, J. L. Hopper, and J. D. Wark Genetic and Environmental Influences on Variation in Balance Performance among Female Twin Pairs Aged 21-82 Years Am. J. Epidemiol., August 1, 2006; 164(3): 246 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Nicklas, J. Mychaleckyj, S. Kritchevsky, S. Palla, L. A. Lange, E. M. Lange, S. P. Messier, D. Bowden, and M. Pahor Physical Function and Its Response to Exercise: Associations With Cytokine Gene Variation in Older Adults With Knee Osteoarthritis J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2005; 60(10): 1292 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Melzer, M. G. Dik, G. J. van Kamp, C. Jonker, and D. J. Deeg The Apolipoprotein E e4 Polymorphism Is Strongly Associated With Poor Mobility Performance Test Results But Not Self-Reported Limitation in Older People J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2005; 60(10): 1319 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pajala, P. Era, M. Koskenvuo, J. Kaprio, A. Tolvanen, E. Heikkinen, K. Tiainen, and T. Rantanen Contribution of genetic and environmental effects to postural balance in older female twins J Appl Physiol, January 1, 2004; 96(1): 308 - 315. [Abstract] [Full Text] [PDF]
|
|
| HOME | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|---|
