Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 52, Issue 2 B98-102, Copyright © 1997 by The Gerontological Society of America

JOURNAL ARTICLE

Effect of age and caloric restriction on cutaneous wound closure in rats and monkeys

GS Roth, MA Kowatch, J Hengemihle, DK Ingram, EL Spangler, LK Johnson and MA Lane
Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, USA. geor@vax.grc.nia.nih.gov

Cutaneous wounds close more slowly in rats and monkeys as age increases. Caloric restriction of 40% in rats and 30% in monkeys did not significantly affect healing rates, although it did exert a trend toward faster closure. Similarly, voluntary exercise did not significantly alter healing rates in rats. Thus, impaired wound healing appears to be a generalized physiological manifestation of aging, but its possible amelioration by "anti-aging" interventions remains to be established.

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