Journals of Gerontology Series A: Biological Sciences and Medical Sciences Large Type Edition
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Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 51, Issue 5 M220-M222, Copyright © 1996 by The Gerontological Society of America

JOURNAL ARTICLE

The relationship of aging to endotoxin shock and to production of TNF- alpha

HN Chang, SR Wang, SC Chiang, WJ Teng, ML Chen, JJ Tsai, DF Huang, HY Lin and YY Tsai
Department of Medicine, Veterans General Hospital, Taipei, Taiwan.

BACKGROUND: Aged people are considered prone to gram-negative bacteremia and septic shock. This relationship was tested in murine endotoxin shock. METHODS: Balb/c mice of various ages (1.4-13.4 months) were intraperitoneally injected with lipopolysaccharide (LPS), and rates of survival were observed. The production of TNF-alpha in vivo induced by LPS was measured. RESULTS: The survival rates were the smallest in the oldest and youngest groups. Production of TNF-alpha attained a maximum at 2 h after LPS injection and was smaller in the oldest group; it had a reciprocal relationship to survival rates in each group except the youngest group. CONCLUSION: Old and young mice had smaller rates of survival and greater production of TNF-alpha following endotoxin shock induced by LPS.




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