| HOME | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|---|
| ||||||||||||||||||||||||||||
Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol 50, Issue 5 B254-B261, Copyright © 1995 by The Gerontological Society of America
JOURNAL ARTICLE |
SA Duhon and TE Johnson
Institute for Behavioral Genetics, University of Colorado, Boulder, USA.
We have asked whether the mutant form of the age-1 gene, which lengthens the life span of the nematode Caenorhabditis elegans up to 70%, also affects the ability to move during this extended period of life. Both age-1 mutants and wild-type controls display a linear loss of movement as the nematodes age. age-1 mutant strains moved faster early in life when compared with non-Age strains and continued low rates of movement at older ages than did non-Age strains. Movement rates were not, in general, a good predictor of movement rates at any later age or of life span. Cumulative lifetime movements of individuals were highly correlated with, and thus a good predictor of, individual life span. These findings are similar to earlier studies of movement in long-lived recombinant-inbred strains of C. elegans and imply that the physiological process altered by the age-1 mutation results in increased health during later life as monitored by increased ability to move.
This article has been cited by other articles:
 |
|
 |
|
  C. F. Glenn, D. K. Chow, L. David, C. A. Cooke, M. S. Gami, W. B. Iser, K. B. Hanselman, I. G. Goldberg, and C. A. Wolkow Behavioral Deficits During Early Stages of Aging in Caenorhabditis elegans Result From Locomotory Deficits Possibly Linked to Muscle Frailty J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2004; 59(12): 1251 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Huang, C. Xiong, and K. Kornfeld Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans PNAS, May 25, 2004; 101(21): 8084 - 8089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Garigan, A.-L. Hsu, A. G. Fraser, R. S. Kamath, J. Ahringer, and C. Kenyon Genetic Analysis of Tissue Aging in Caenorhabditis elegans: A Role for Heat-Shock Factor and Bacterial Proliferation Genetics, July 1, 2002; 161(3): 1101 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Johnson, D. Wu, P. Tedesco, S. Dames, and J. W. Vaupel Age-Specific Demographic Profiles of Longevity Mutants in Caenorhabditis elegans Show Segmental Effects J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2001; 56(8): B331 - 339. [Abstract] [Full Text] [PDF]
|
|
| HOME | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|---|
